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Wellbutrin is an antidepressant available as brand or generic (Bupropion).
Below are the most frequently asked questions about Wellbutrin (Bupropion). Be sure to also take a look at our Depression & Anxiety FAQ .
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Wellbutrin tips
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:: What are Wellbutrin, Wellbutrin SR and Bupropion?
Wellbutrin, Wellbutrin SR and Bupropion are FDA-approved oral prescription antidepressant medications used for the treatment of major depression.
Wellbutrin is the brand name formulation of immediate release Bupropion. Wellbutrin SR is the brand name formulation of Sustained Release Bupropion.
Wellbutrin and Wellbutrin SR are manufactured by GlaxoSmithKline Inc., based in Philadelphia, Pennsylvania, USA.
Bupropion is generic immediate release Wellbutrin, and is available from various US manufactures.
* Be sure to take a look at our comprehensive Depression & Anxiety FAQ to learn more about depression, anxiety disorders, other mood disorders and for a
comparison of the advantages and disadvantages of the commonly prescribed antidepressant and anti-anxiety medications .
You can buy Wellbutrin by going to our Wellbutrin price comparison page where you can select your preferred online US pharmacy with the lowest Wellbutrin prices, no prior prescription required.
Or if you prefer generic, you can buy Bupropion (generic Wellbutrin) by going to our Bupropion price comparison page .
If it's your first time ordering Wellbutrin online, see our beginner’s guide , where the process of obtaining a prescription online and ordering your medication is explained.
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:: Who should take Wellbutrin (Bupropion)?
Wellbutrin (Bupropion) should be used by adults diagnosed with major depressive disorder.
If you'd like to learn more about depression and other mood conditions, they are discussed in detail in our extensive Guide to Depression and Anxiety .
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:: Who should not take Wellbutrin (Bupropion)?
You should not take Wellbutrin (Bupropion) if you:
- Have or have had a seizure disorder (epilepsy).
- Are already taking Zyban, Wellbutrin SR, Wellbutrin XL, or any other medicines
that contain bupropion hydrochloride
- Have or have had an eating disorder (bulimia or anorexia nervosa).
- Are abruptly discontinuing use of alcohol or sedatives (including benzodiazepines).
- Are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI).
- Are allergic to bupropion.
It is important to let your doctor know about any prescription or over-the-counter medications you are taking, and if you have or have had other medical conditions especially head injury, brain tumor, heart disease, high blood pressure, liver problems, kidney problems, diabetes and alcohol or drug dependence.
There is no evidence of impaired fertility or harm to the fetus due to bupropion. But there are no adequate and well-controlled studies in pregnant women. Wellbutrin (Bupropion) should be used during pregnancy only if clearly needed. Bupropion is secreted in human milk, which can lead to the potential for serious adverse reactions in nursing infants. Nursing mothers must either stop nursing or discontinue Wellbutrin (Bupropion). Women should notify their doctor if they become pregnant or intend to become pregnant while taking Wellbutrin (Bupropion).
When used with a nicotine patch or alone, there is a risk of increased blood pressure, sometimes severe. Let your doctor know if you have hypertension (high blood pressure).
Wellbutrin (Bupropion) should be used with extreme caution in patients with severe liver disease. If you have liver or kidney problems, tell your doctor before taking Wellbutrin (Bupropion). Depending on the severity of your condition, your doctor may need to adjust your dosage.
Only your healthcare provider can tell you for sure if you should or not take Wellbutrin (Bupropion). Inform your healthcare provider, during either a physical or online consultation, about all the medicines you are taking, prescription or over-the-counter, and about any medical conditions you have or have had, including allergies.
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:: What is depression?
This question requires its own frequently asked questions page.
Please see our extensive Depression and Anxiety FAQ page for information describing each of the following conditions, its causes, symptoms and treatment options:
- Depression .
- Premenstrual dysphoric disorder (PMDD) .
- Anxiety disorders:
generalized anxiety disorder (GAD) ,
panic disorder ,
social anxiety disorder ,
obsessive-compulsive disorder (OCD) , and
posttraumatic stress disorder (PTSD) .
- Eating disorder: bulimia nervosa .
There, you will also find clear summary tables listing:
- The different classes of commonly prescribed antidepressant and anti-
anxiety medications
- The various conditions each of the medications is used for
- A comparison of their advantages and disadvantages
- A list of simple things you can do to help improve the symptoms of your
depression and anxiety
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:: How does Wellbutrin (Bupropion) work?
Depression is believed to be caused by an imbalance of the brain’s neurotransmitters, the chemicals that allow nerve cells to communicate. Bupropion is a weak inhibitor of the reuptake of the neurotransmitters, norepinephrine, serotonin, and dopamine, leading to increased levels of these chemicals.
Although it not known exactly how Wellbutrin (Bupropion) works to help patients with major depressive disorder, it is believed that its antidepressive action is a result of its action on these neurotransmitters.
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:: How well does Wellbutrin (Bupropion) work?
Three clinical studies have shown that bupropion is an effective treatment for major depressive disorder. In all three studies, patients receiving bupropion showed improvement of the Depressive Rating Scales used to measure depression symptoms compared to sugar pill.
A fourth study showed that patients who had responded to 8 weeks of bupropion therapy who continued taking bupropion had significantly lower depression relapse rates over 44 weeks compared to those receiving sugar pill.
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:: How safe is Wellbutrin (Bupropion)?
Wellbutrin has been used as an antidepressant since 1985. Its safety and efficacy profile has been maintained by real-world experience as well as clinical trials.
Wellbutrin (Bupropion) has been approved by the FDA to successfully and safely treat major depressive disorder. However, it may not be right for everyone. Be sure to read Who should not take Wellbutrin? .
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:: What is the difference between Wellbutrin SR, Wellbutrin,
Bupropion and Zyban?
The active ingredient in Wellbutrin SR, Wellbutrin, Bupropion and Zyban are all the same, bupropion. The only difference is the rate at which the medication is absorbed by your body:
Wellbutrin and Bupropion are considered immediate release and are taken three times daily.
Wellbutrin SR (sustained release) releases the medication into your system at a slower rate therefore only has to be taken two times daily.
Zyban is available as a 150mg sustained release tablet, which is taken twice daily to help smokers quit smoking. See our Zyban FAQ to find out more.
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:: What is the difference between Wellbutrin (Bupropion) and other
antidepressants?
Studies comparing the effectiveness of various antidepressants such as Wellbutrin (Bupropion) have shown that, when properly dosed, they are equally effective in treating depression and other disorders. Therefore medications like Wellbutrin (Bupropion) should be chosen based on different side effects profiles and different drug or disease interactions.
See What are the advantages and disadvantages of commonly prescribed antidepressants and anti-anxiety medications? for a table comparing the different drugs and their classes,
in our Depression and Anxiety FAQ .
Wellbutrin (Bupropion) is approved to treat depression. Learn which conditions other antidepressants are approved to treat.
See What conditions do various antidepressant and anti-anxiety medications treat? in our Depression and Anxiety FAQs
It's important to keep in mind that not everyone responds the same to individual drugs. A different drug in the same or different class may work for you when the first did not. It may take more than one try to find the right medication for you.
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:: What does Wellbutrin (Bupropion) look like?
Wellbutrin is available as brand and generic, and is produced by different companies. Some of the most common Wellbutrin and Bupropion pills for the US market are shown here. Your Wellbutrin or Bupropion pills may look different, consult your physician or pharmacist if you have any questions.
Brand Wellbutrin
Wellbutrin is manufactured by GlaxoSmithKline Inc., based in Philadelphia, Pennsylvania, USA, in the following formulations:
- Wellbutrin SR 100mg Sustained-Release tablets are round, film-coated and blue, with WELLBUTRIN SR 100 printed in black on one side, and nothing on the other side.
- Wellbutrin SR 150mg Sustained-Release tablets are round, film-coated and purple, with WELLBUTRIN SR 150 printed in black on one side, and nothing on the other side.
- Wellbutrin SR 200mg Sustained-Release tablets are round, film-coated and pink, with WELLBUTRIN SR 200 printed in black on one side, and nothing on the other side.
- Wellbutrin 75mg tablets are round, yellow-gold, with the imprint WELLBUTRIN 75 on one side, and nothing on the other side.
- Wellbutrin 100mg tablets are round, red, with the imprint WELLBUTRIN 100 on one side, and nothing on the other side.
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Generic Wellbutrin: Bupropion
Bupropion is available from Teva Pharmaceuticals based in North Wales, Pennsylvania, USA in the following formulations:
- Bupropion 75mg tablets are round, film-coated and yellow, with the imprint 93 280 on one side, and nothing on the other side.
- Bupropion 100mg tablets are round, film-coated and pink, with the imprint 93 290 on one side, and nothing on the other side.
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Bupropion is available from Sandoz Pharmaceuticals Princeton, New Jersey, USA in the following formulations:
- Bupropion 75mg tablets are round, film-coated and lavender, with the imprint GG 929 on one side, and nothing on the other side.
- Bupropion 100mg tablets are round, film-coated and lavender, with the imprint GG 930 on one side, and nothing on the other side.
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Bupropion is available from Mylan Pharmaceuticals based in Morgantown, New Jersey, USA in the following formulations:
- Bupropion 75mg tablets are round, pink, with the imprint M on one side, and 433 on the other side.
- Bupropion 100mg tablets are round, blue, with the imprint M on one side, and 435 on the other side.
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Depending on the manufacturer, your tablets may look different.
Please be sure to consult your physician or pharmacist if you have any questions.
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:: How do I take Wellbutrin (Bupropion)?
All formulations of bupropion can be taken with or without food. As bupropion may cause sleeplessness at first avoid taking a dose late in the day.
Wellbutrin SR (Sustained-Release)
- Usual Adult Dose: Oral dosage form (Sustained-Release Tablets)
Wellbutrin SR (bupropion) comes in 100mg, 150mg and 200mg Sustained Release tablets. Wellbutrin SR should be swallowed whole and not crushed, divided, or chewed. The starting dose is usually 150mg once daily in the morning then based on response this dose can be increased after three days to 150mg twice daily with at least 8 hours between each dose. Doses above 400mg/day should not be used.
Wellbutrin (brand) or Bupropion (generic)
- Usual Adult Dose: Oral dosage form (Tablets)
Wellbutrin (Bupropion) comes in 75mg and 100mg (immediate release) tablets. The starting dose is usually 100mg twice daily then based on response this dose can be increased after three days to 100mg three times daily with at least 6 hours between each dose. The maximum single dose is 150mg. Doses above 450 mg/day should not be used.
You should take Wellbutrin (bupropion) or Wellbutrin SR as directed by your doctor. Do not take more medication than prescribed. This is very important so you do not increase your chance of having a seizure.
* It usually takes 1 to 2 weeks for Wellbutrin (Bupropion) to take effect. Once you feel better, keep taking Wellbutrin as directed by your doctor. Do not change your dose or stop taking it without consulting your doctor.
Your doctor may have a plan that varies from above, always follow your doctor’s recommendations.
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:: What should I do if I miss a dose of Wellbutrin (Bupropion)?
Do not take an extra tablet of Wellbutrin (Bupropion) to make up for a missed dose. Wait and take your next tablet at the regular time. Do not take more tablets than your doctor prescribed as this may increase your chance of having a seizure.
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:: How long should I continue to use Wellbutrin (Bupropion)?
The initial treatment of major depression is 6 to 8 weeks to reduce and eliminate symptoms. After the initial treatment, medical guidelines recommend that you continue antidepressant therapy for 4 to 9 months. This is important because continuing Wellbutrin (Bupropion) can lower your risk of relapse (getting depressed again) by 70%. Therapy beyond this period may be recommended if you have a history of multiple recurrent depressive episodes. Your doctor will let you know how long you should continue therapy. Always follow your doctor’s instructions.
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:: How should I store Wellbutrin (Bupropion)?
Keep Wellbutrin (Bupropion) and all medications out of children's reach.
Store Wellbutrin (Bupropion) at room temperature in a tight container. Store away from moisture, heat and direct light. Do not keep medicine past the expiration date, dispose of properly.
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:: What are the possible side effects of Wellbutrin (Bupropion)?
The most common side effects of Wellbutrin (Bupropion) are nausea, stomach pain, weight loss, loss of appetite, dry mouth, sore throat, ringing in the ears, sweating, shakiness, agitation, anxiety, dizziness, trouble sleeping, muscle pain, fast heartbeat, and urinating more often.
These side effects are usually mild and will often go away after a few weeks. If you have difficulty sleeping, avoid taking a dose late in the day (but make sure at least 8 hours have passed since your morning dose). If you have nausea, take Wellbutrin (Bupropion) with food.
Stop taking Wellbutrin (bupropion) and contact your doctor immediately if you have signs of an allergic reaction such as a rash, hives, difficulty breathing, swollen lymph glands, painful sores in the mouth or around the eyes, or swelling of lips or tongue.
Hypertension (high blood pressure), sometimes severe, has been reported in patients taking Wellbutrin (Bupropion) alone or with nicotine replacement products.
There is a chance that approximately 1 out of every 1,000 Wellbutrin (Bupropion) users will have a seizure. See Who should not take Wellbutrin (Bupropion)? . The chance of this happening increases if you:
- Have or have had a seizure disorder (epilepsy)
- Have or have had an eating disorder (bulimia or anorexia nervosa)
- Are abruptly discontinuing use of alcohol or sedatives (including benzodiazepines)
- Take more than the recommended amount of Wellbutrin (bupropion)
- Take other medicines with bupropion hydrochloride, the same active ingredient
that is in Wellbutrin, such as Zyban, Wellbutrin SR, Wellbutrin XL, or other
generic bupropion preparations.
To reduce the chance of experiencing a seizure. always take Wellbutrin (Bupropion) as directed by your doctor. If you experience a seizure while taking Wellbutrin (Bupropion), stop taking the tablets immediately, contact your doctor, and do not restart Wellbutrin (Bupropion).
Side effects of Wellbutrin (Bupropion) other than those listed here may also occur. Talk to your doctor about any side effects that seem unusual or that are especially bothersome.
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:: Will I gain weight while taking Wellbutrin (Bupropion)?
Wellbutrin (Bupropion) does not usually cause weight gain, but it can cause weight loss. As many as 14 to 28% of patients in studies reported weight loss while taking Wellbutrin (Bupropion).
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:: Will Wellbutrin (Bupropion) affect my sex drive?
Wellbutrin (Bupropion) has a low risk of sexual side effects. Studies show that the occurrence of sexual side effects is the same as with sugar pill. Other antidepressants including SSRIs such as Prozac, Zoloft, Paxil and others have a higher risk of sexual side effects.
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:: What other precautions should I take when taking Wellbutrin
(Bupropion)?
In addition to the above possible side effects of Wellbutrin (Bupropion), please be aware of the following as they apply to you.
Driving and Hazardous Work:
Wellbutrin (Bupropion) may make you dizzy or affect your coordination. Use caution before driving a car or engaging in hazardous work until you know how the medicine affects you.
Consumption of Alcohol:
Limit or avoid drinking alcoholic beverages while taking Wellbutrin (Bupropion) as alcohol can increase your risk of having a seizure.
Bupropion-containing products:
Do not take other bupropion-containing products while using Wellbutrin such as Zyban, Wellbutrin SR, Wellbutrin XL, or generic bupropion preparations as this may increase your chance of having a seizure.
Pregnancy and Breast Feeding:
Wellbutrin (Bupropion) should be used during pregnancy only if clearly needed, as there are no adequate and well-controlled studies in pregnant women. Bupropion is secreted in human milk, which can lead to potential risk to nursing infants. Nursing mothers must either stop nursing or discontinue Wellbutrin (Bupropion). Women should notify their doctor if they become pregnant or intend to become pregnant while taking Wellbutrin (Bupropion).
Sensitivity to Sunlight: Wellbutrin (Bupropion) may increase sensitivity to sunlight. Use sunscreen and avoid extended exposure to sunlight until you know how Wellbutrin (Bupropion) affects you.
Kidney and Liver Disease:
The side effects may be more likely due to potential for higher blood levels of bupropion. Depending on the severity of your condition, your doctor may need to adjust your dose.
Mood Changes:
You and your family should watch out for sudden or severe changes in feelings such as feeling anxious, agitated, severely restless, hyperactive, overly excited, panicky, irritable, hostile, aggressive, impulsive, not being able to sleep, worsening depression or thoughts of suicide. These symptoms should be reported to your doctor immediately.
Do NOT share your Wellbutrin (Bupropion) prescription with others; this can be a very dangerous practice.
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:: What are the possible drug interactions of Wellbutrin (Bupropion)?
Inform your doctor, during either a physical or online consultation, about all the medicines you use, (prescription and nonprescription). Certain medicines should never be used together. Some medicines may be used together even if an interaction might occur. In these cases, your doctor may change the dose, monitor the effects or take other precautions.
When you are taking Wellbutrin (Bupropion), it is especially important that you inform your doctor if you are taking any of the following:
- Nicotine replacement products (gum, patch, lozenge, spray or inhaler) - risk of increased blood pressure.
- Monoamine Oxidase (MAO) inhibitors: Furoxone (furazolidone), Nardil (phenelzine), Eldepryl (selegiline), Marplan (isocarboxazid), Matulane (procarbazine), Parnate (tranylcypromine) - there should be at least 14 days between stopping a MAO inhibitor and starting Wellbutrin (Bupropion).
- Tricyclic antidepressants such Elavil (amitriptyline), Anafranil (clomipramine), Asendin (amoxapine), Sinequan (doxepin), Aventyl/Pamelor (nortriptyline), Surmontil (trimipramine), Norpramin (desipramine), Tofranil (imipramine), Vivactil (protriptyline) - increased risk of seizure.
- Phenothiazines (thioridazine), isoniazid (INH), theophylline, systemic steroids, over-the-counter stimulants and weight loss medications, oral hypoglycemics or insulin, and others - increased risk of seizure.
- Sinemet (levodopa), Symmetrel (amantadine), Norvir (ritonavir) - risk of increased side effects.
- Certain antidepressants: Paxil (paroxetine), Prozac (fluoxetine), Zoloft (sertraline), Celexa (citalopram), and Lexapro (escitalopram); antipsychotics: Haldol (haloperidol), Risperdal (risperidone), Mellaril (thioridazine); beta-blockers: Lopressor (metoprolol); and antiarrhythmics: Rhythmol (propafenone), Tambocor (flecainide) - Wellbutrin (Bupropion) increases these medications’ potency.
Drugs other than those listed here may also interact with Wellbutrin (Bupropion).
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:: Can I drink alcohol while taking Wellbutrin (Bupropion)?
It is best to avoid drinking alcohol or to drink very little while taking Wellbutrin (Bupropion). Drinking a lot of alcohol then stopping suddenly may increase your chance of having a seizure. Some people have reported lower alcohol tolerance while they are taking Wellbutrin (Bupropion). Discuss your use of alcohol with your doctor before you start taking Wellbutrin (Bupropion).
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:: Can I become dependent on Wellbutrin (Bupropion)?
The potential for becoming dependent on Wellbutrin (Bupropion) is unlikely when used at recommended doses. There may be a slight chance for abuse by those who abuse stimulant drugs.
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:: What are the symptoms of a possible overdose of Wellbutrin
(Bupropion)?
Symptoms of overdose may include blurred vision, lightheadedness, confusion, nausea, and seizures.
If overdose is suspected, call your doctor, emergency medical services (EMS) 911, or the poison control center immediately.
National Poison Control Center Telephone Number: 800-222-1222
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:: Is Wellbutrin (Bupropion) available over the counter?
No. Wellbutrin (Bupropion) is currently available by prescription only.
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:: How can I get a Wellbutrin (Bupropion) prescription online?
Go to our Wellbutrin price comparison page where you can select your preferred online US pharmacy with the lowest Wellbutrin prices, no prior prescription required.
Or if you prefer generic, you can buy Bupropion (generic Wellbutrin) by going to our Bupropion price comparison page .
Our featured US-based online pharmacies work with US-licensed doctors and pharmacists to provide you with your prescriptions through an online consultation.
If this is your first time ordering Wellbutrin online, see our beginner’s guide , where the process of obtaining a prescription online and ordering your medication is explained.
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:: How much does Wellbutrin (Bupropion) cost?
Some companies charge less per pill but charge you separately for their consultation and pharmacy dispensing fees. Others include these fees into their final pricing.
RxPriceCheck's featured pharmacies give you a free online medical consultation with your order. Be sure to compare Wellbutrin prices before buying.
There is brand Wellbutrin and generic Wellbutrin (Bupropion) available. Be sure to compare Wellbutrin prices and Bupropion prices before buying.
Usually, the more tablets you buy, the cheaper the price per tablet.
Generic Wellbutrin is usually cheaper than brand, especially as quantities increase. Brand or generic is really up to your preference.
Go to our Wellbutrin price comparison page where you can select your preferred online US pharmacy with the lowest Wellbutrin prices, no prior prescription required.
Or if you prefer generic, you can buy Bupropion (generic Wellbutrin) by going to our Bupropion price comparison page .
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:: What is generic Wellbutrin (Bupropion) and is it available?
Bupropion is the generic name for Wellbutrin. Wellbutrin (brand) is available in 5, 10, 15 and 30 mg tablets, and Bupropion (generic) is available in 5, 7.5, 10, 15 and 30 mg tablets from various US manufacturers. For pictures and manufacturer information, see What does Wellbutrin (Bupropion) look like? .
Generic is usually cheaper than brand. Brand or generic is really up to your preference.
Go to our Bupropion price comparison page where you can select your preferred online US pharmacy with the lowest Bupropion prices, no prior prescription required.
Compare with Wellbutrin prices
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:: Is it safe to order Wellbutrin (Bupropion) or other medications
from non-US pharmacies?
Purchasing Wellbutrin or Bupropion from non-US pharmacies can be potentially dangerous. The FDA (Food and Drug Administration) does not recommend ordering medications online from pharmacies located outside the U.S. because it cannot guarantee the origin, quality or safety of the medication or regulate the manufacturers. Therefore, it may be filled with other ingredients that may harm you, or it may be fake, sold as Wellbutrin, but not contain the active ingredient bupropion hydrochloride.
RxPriceCheck.com only affiliates with online US pharmacies that work with US licensed physicians and pharmacists, and sell brand Wellbutrin or generic Bupropion approved by the FDA. You can therefore choose from our list of online US pharmacies with confidence.
See our Wellbutrin price comparison page where you can select your preferred online US pharmacy with the lowest Wellbutrin prices, no prior prescription required.
Or if you prefer generic, you can buy Bupropion (generic Wellbutrin) by going to our Bupropion price comparison page .
Also see our extensive Guide to Depression and Anxiety to learn more about mood disorders, and to see our comparison of Wellbutrin (Bupropion) to other anti-anxiety medications.
If this is the first time that you are ordering Wellbutrin (Bupropion) online, see our beginner’s guide , where the process of obtaining a prescription online and ordering your medication is explained.
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* The information contained in RxPriceCheck.com is for educational purposes only and is not intended as medical advice. Consult your healthcare provider regarding your medical condition. All product names are trademarks or registered trademarks of their respective holders. View our terms of use .
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